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lumacaftor/ivacaftor will reduce the level or impact of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with robust CYP3A4 inducers lowers plasma focus of abemaciclib and its metabolites.When you have had any liver an infection or been explained to you may have inf